INS and metabolic syndrome: 2004; Bonora et al. 2007; Verhagen et al. 2011). Recently, a large meta-analysis substantiated the association between metabolic syndrome and cardiovascular disease (Mottillo et al. 2010). Insulin resistance is a central component of both metabolic syndrome and DS. Several reports (Baykan et al. 2008; Nobile et al. 2012; Hovnik et al. 2013) argue that the underlying mechanisms for cardiomyopathy in DS and metabolic syndrome involve excess insulin activation of Insulin-like growth factor 1 (IGF1) receptors [6].