APC and colorectal carcinoma: APC is a well-known target during the early stages of colon cancer: truncation of the APC protein occurs in >80% of colorectal cancers (CRC) (Rowan et al. 2000) and it is associated with the initial stages of oncogenic transformation (Kinzler and Vogelstein 1997; Jones et al. 2008), which suggests a functional role for our newly identified splicing variant.