By using our procedure we identified a novel somatic, intronic mutation affecting a splicing site in APC. Then we applied the SpliceFinder to whole-exome sequencing data from eight chronic myeloid leukemia (CML) and eight atypical chronic myeloid leukemia (aCML) (Vardiman et al. 2009) patient samples including matched autologous normal lymphocytes; RNA-Seq data were used to evaluate the relative mRNA abundance (SRA061202, GSE42146) and the splicing gene profiles. This evidence concerns the gene APC and chronic myelogenous leukemia, BCR-ABL1 positive.