DMD and Duchenne muscular dystrophy: It was considered unlikely that nonsense-mediated decay alone could account for what appeared to be extremely low levels of transcript, as we routinely detect dystrophin transcripts in many different DMD patient cell and tissue samples, under equivalent amplification conditions (Arechavala-Gomeza et al. 2007; Forrest et al. 2010; Fragall et al. 2011; Adkin et al. 2012).