SIX6 and autosomal dominant nonsyndromic hearing loss: This deletion encompassed 36 genes in addition to OTX2, including the known disease genes SIX6 (MIM# 606326 Microphthalmia with cataract 2 – discussed below), SIX1 (MIM# 601205 Brachiootic syndrome 3 and deafness, autosomal dominant 23), and PRKCH (MIM# 605437 susceptibility to cerebral infarction).