Recent proteomic studies of patients with diabetic neuropathy have identified a number of proteins, including a fragment of the apolipoprotein C-I precursor, that associate with diabetic neuropathy.88 Metabolomic studies have identified phospholipid biomarkers that may improve discrimination between those DM patients with and without neuropathy.89 Such advances may lead to improved assessment of neuropathy risk and may enhance understanding of the pathophysiology of diabetic neuropathy. Here, APOC1 is linked to diabetic neuropathy.