Interestingly, although a subset of genes (MAP3K10, NFKBIB, NUMBL and B3GNT8), maintained coordinate control in smokers (r2 = 0.80, p<10−3), the overall mean coordinate control of the 13 BC smoking-dysregulated genes in smokers was lost (mean r2 = 0.48 in smokers; p = 0.26) compared to what would be expected by chance (Figure 4B). This evidence concerns the gene MAP3K10 and breast cancer.