Strikingly, however, 13 of 676 (2%) BC smoking-dysregulated genes were significantly localized to chromosome subband 19q13.2 (p<10−4, Figure 2C), including NFKBIB, PAK4, DYRK1B, MAP3K10, SERTAD1, LTBP4, NUMBL, EGLN2, TGFB1, B3GNT8, RABAC1, CIC and MEGF8 (Figure 3A). This evidence concerns the gene PAK4 and breast cancer.