CREB3L1 and colitis: We found that loss of OASIS function leads to increased susceptibility to DSS-induced colitis based on the following results: 1) Oasis−/− mice showed loss of body weight and increased mortality after exposure to DSS; 2) the mucosa of the large intestine in Oasis−/− mice showed severe damage involving degeneration and inflammation compared with that in WT mice; 3) ER stress-induced apoptosis was accelerated in the mucosal epithelium of the Oasis−/− large intestine.