TIMP1 and hepatocellular carcinoma: Tak1HepKO mice exhibited signs of highly increased liver damage including increased levels of serum aminotransferase (ALT), expression of chemokine (C-X-C motif) ligand 2 (Cxcl2), chemokine (C-C motif) ligand 2 (Ccl2), fibrosis markers, collagen, type I, α1 (Col1a1) and tissue inhibitor of metalloproteinase 1 (Timp1) as well as hepatocellular carcinoma marker, H19 gene within one month even in the absence of any exogenous stressors (Fig. S2), consistent with earlier studies.