Tak1HepKO mice exhibited signs of highly increased liver damage including increased levels of serum aminotransferase (ALT), expression of chemokine (C-X-C motif) ligand 2 (Cxcl2), chemokine (C-C motif) ligand 2 (Ccl2), fibrosis markers, collagen, type I, α1 (Col1a1) and tissue inhibitor of metalloproteinase 1 (Timp1) as well as hepatocellular carcinoma marker, H19 gene within one month even in the absence of any exogenous stressors (Fig. S2), consistent with earlier studies. This evidence concerns the gene CXCL2 and hepatocellular carcinoma.