Sass et al. [28] explored the changes in cytokine expression in three mouse models of experimental hepatitisand found that the levels of IL-2 and IL-6 increased from 3h after the administration of Con A. It has also been reported that various concentrations of IL-2 played different roles in Con A-induced autoimmune hepatitis; a low dose of IL-2 exacerbated Con A-induced liver injury as reported by Zhang et al. [29]. This evidence concerns the gene IL2 and autoimmune hepatitis.