The effect of recombinant REIC/Dkk-3 protein on NSCLC cell lines was examined in 7 randomly selected cell lines (NCI-H522, NCI-H611, NCI-H1299, NCI-H1819, NCI-H2009, PC-9, and A549). The gene discussed is DKK3; the disease is non-small cell lung carcinoma.