PK-8, PCI-35, and MIA PaCa2 are pancreatic cancer cell lines harboring the following gain-of-function mutations of KRAS: G12R in PK-8 cells, G12D in PCI-35 cells, and G12C in MIA PaCa-2 cells, but no mutations in the mutational hotspots of exons 8 and 9 (including codons 201 and 227) of GNAS[3]. The gene discussed is GNAS; the disease is familial pancreatic carcinoma.