However, conflicting data have been published related to either tumor-promoting or -suppressing activities of JARID1B, JMJD3 and JMJD2C, suggesting that the overall effect in cancer may be context-dependent and rely on concerted action of multiple epigenetic enzymes and/or combinatorial posttranslational modifications of nucleosomes and transcription factors [53]–[59]. This evidence concerns the gene KDM5B and cancer.