ANGPTL2 and neoplasm: On the contrary, in our experimental set up WA decreased EMT-related components of the TGF-β signaling pathway (TGFA, TGFBR2, CDH11 [47], [48]), as well as TGM2, HIF1A, several TNFSF family members and ANGPTL2, which stimulate tumor promoting pro-inflammatory responses and a hypoxic microenvironment.