Additional repressed genes were ANGPTL2, TGM2, IL-6, CSF1R, TNFSF12 as well as a key regulatory MAP kinase ERK1/2 (MAPK3), all known to stimulate chronic inflammatory signaling in the tumor microenvironment and to promote cancer metastasis [28]–[32]. This evidence concerns the gene ANGPTL2 and neoplasm.