TNF and acne: The meta-analysis results showed that TNF -308 G/A polymorphism was linked to the risk of acne vulgaris under recessive and additive models ( AA vs. AG + GG: OR = 2.73, 95%CI: 1.37–5.44, p = 0.004; AA vs. GG: OR = 2.67, 95%CI: 1.28–5.57, p = 0.009; respectively) (Figure 2).