TICAM1 and viral infectious disease: The analysis of the “HDM core response” genes [10] in response to HDM in the airway epithelium revealed a dysregulation of genes directly linked to the defense against viral infections, namely TLR3, TICAM1, and IVNS1ABP. Another study has shown a significantly down-regulated baseline expression of the TLR3 gene in nasal epithelium of house dust mite allergic individuals [9].