Similar signs of axonopathy with reduction in the axonal caliber followed by degeneration at the later stages have been reported for transgenic mice lacking myelin proteins such as 2′,3′cyclic nucleotide 3′-phosphodiesterase, proteolipid protein and myelin-associated glycoprotein [41], [42] as well as in autopsies from MS brain [37]. The gene discussed is MAG; the disease is myeloid sarcoma.