Furthermore, Schug et al. showed that ablation of SIRT1 in macrophages not only increased the inflammatory response but also predisposed mice to the development of insulin resistance and metabolic disorders [10], and our data demonstrated that myeloid cell-specific SIRT1 deletion led to enhanced inflammation and bone destruction in K/BxN serum transfer arthritic mice. Here, SIRT1 is linked to metabolic disease.