TMPRSS11B and squamous cell carcinoma: Given the expression of HATL5 in the non-proliferating suprabasal/apical layers coupled with the observation that HATL5 is lost during the dedifferentiation of epithelial cells, a hallmark of squamous cell carcinogenesis, it will be important to explore whether the observed link between loss of HATL5 and squamous cell carcinoma progression is correlational or causal.