CTNNB1 and lung cancer: Analysis of the CTNNB1 gene promoter region (−1,124–11,114 bp) revealed the presence of two CpG islands (Fig. 1A), and treatment of lung cancer cell lines with 5-Aza-CdR (7 μmol/L) for 48 h resulted in varying levels of increased β-catenin mRNA expression (Fig. 1B).