In this study, besides confirming the associations between PNPLA3 C>G SNP and steatosis/lobular inflammation [11]–[15], for the first time we also highlighted the potential impact of GCKR C→T SNP on liver fibrosis in an European cohort of histologically diagnosed NAFLD patients. This evidence concerns the gene PNPLA3 and metabolic dysfunction-associated steatotic liver disease.