Besides the classical PNPLA3, a recent genome wide study identified other genetic variants associated with computerized tomography (TC)-proven hepatic steatosis in individuals of European ancestry, and validated the results in 592 subjects with biopsy-proven NAFLD from the NASH Clinical Research Network (NASH CRN) database [19]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.