CHUK and atherosclerosis: Therefore, we investigated the effect of a BM-specific non-activatable IkkαAA knock-in on haematopoiesis in conditions of atherosclerosis and identified a significant reduction in the B-cell population in the blood and lymph nodes of hyperlipidaemic IkkαAA/AAApoe−/− BM chimeras in comparison with Ikkα+/+Apoe−/− BM-transplanted Apoe−/− controls (Figure 1A, Figure S1).