To study the role of IKKα kinase activation in haematopoiesis in the context of atherosclerosis, BM was isolated from Ikkα+/+Apoe−/− or IkkαAA/AAApoe−/− mice, the latter carrying an non-activatable mutant of Ikkα through replacement of serines 176/180 in its activation loop with alanine residues [22]. Here, CHUK is linked to atherosclerosis.