SPI1 and acute myeloid leukemia: Recruitment of CTCF and SMARCA5 onto the SPI1 gene in mixed myeloid cells as well as in AZA-treated OCI-M2 blasts indicated that CTCF and SMARCA5 might regulate the transcriptional outcome of SPI1. In order to address this possibility we decided to manipulate the levels of CTCF and SMARCA5 in human AML OCI-M2 blasts.