Immunohistochemical (IHC) staining showed that BMP-6 expression was decreased in 46% of HCC cases (34 of 75), BMP-6 expression was unchanged in 47% of HCC cases (35/75), and BMP-6 expression was increased in 7% of HCC cases (6 of 75) (Figure 5A). The gene discussed is BMP6; the disease is hepatocellular carcinoma.