Specifically, complete suppression of rd7 retinal degeneration was observed in outcrosses of B6.Cg-Nr2e3rd7/rd7 mice to AKR/J, CAST/EiJ or NOD.NOH-H2nb1 mice and several modifier loci that were unique for each strain were identified [40]. The gene discussed is NR2E3; the disease is retinal degeneration.