Delivery of the Nr1d1 gene to the retinas of B6.Cg-Nr2e3rd7/rd7 neonates rescues retinal spotting and retinal dysplasia associated with Nr2e3 loss, confirming that increased Nr1d1 expression is sufficient for suppressing rd7. Importantly, we show that Nr1d1 delivery results in re-regulation of key genes within the Nr2e3-directed network that are essential for proper photoreceptor function. The gene discussed is NR2E3; the disease is retinitis.