NOS2 and amyotrophic lateral sclerosis: We also detected an increased level of iNOS in the extract from lumbar spinal cord of vehicle-treated ALS(SOD1H46R) mice at 21–22 weeks of age compared to those in non-Tg littermates (Figure 6C), whereas the WN1316 treatment decreased iNOS generation in ALS(SOD1H46R) mice (Figure 6C).