FADS2 and hyperhomocysteinemia: The possible methylation silencing of liver FADS2 expression was also found in the study of Devlin et al. [64] which revealed that mice with FADS2 promoter hypermethylation caused by hyperhomocysteinemia also showed lower FADS2 mRNA (P<0.01) and lower Δ6 desaturase activity (P<0.001) in liver.