By day 35 post infection, TMEV was no longer detected by immunohistochemistry in Vα14 Tg mice (0 out of 7 mice) or wild-type mice (0 out of 6 mice), only in H2-Db -/- + H2-Kb -/- that lack a CD8 T cell compartment could we detect presence of TMEV in the hippocampus and cortex (4 out of 8 mice, data not shown). The gene discussed is CD8A; the disease is infection.