Five of them (patients with hereditary hemolytic anemia, sepsis, hemophilia A (24 hours after hip joint surgery), multiple myeloma and pneumonia, or lymphogranulomatosis during chemotherapy) had increased microparticles amounts, the means being 2070±620 PS+, 1220±720 CD61+ microparticles/μl. The gene discussed is PRB2; the disease is Sepsis.