Loss of function of GATA4 ∼ 6 by promoter hypermethylation [13]–[15] or nucleocytoplasmic mislocalization [16], [17] is a common event in carcinoma of lung, digestive tract, pancrea and ovarian, which causes loss of expression of epithelial-specific markers (disabled-2, collagen IV and laminin) leading to cellular dedifferentiation and down-regulates potential targets of tumor suppressor genes (the trefoil factors, inhibin and disabled-2). The gene discussed is GATA4; the disease is carcinoma.