However, further experiments are needed to address how does liver gain ectopic expression of hematopoietic factor GATA2 with concomitant loss of endoderm factors GATA4 ∼ 6 and how, if that exists, do these factors cooperate or compete with each other in the progression of hepatocellular carcinoma. This evidence concerns the gene GATA2 and hepatocellular carcinoma.