Previous studies haveindicated that OPN is involved in tumor metastasis and has been detected in numerouscancers including HCC, suggesting a correlation between high levels of OPNexpression and malignant invasion [21], [23].Studies have also shown higher levels of OPN during liver injury, inflammation aswell as in the plasma of HCV related HCC patients than in healthy individuals [42]–[46]. Here, SPP1 is linked to hepatocellular carcinoma.