Figure 3b shows the random-effects meta-analytic model of carriers of any Ala allele (heterozygote or homozygote Ala allele) of SOD2 and breast cancer outcomes, compared with wild-type homozygotes. The summary random-effects estimate was 1.18 (95%CI = 0.91, 1.54). We used the trim and fill method to calculate an adjusted pooled random-effects effect estimate [27]. This evidence concerns the gene SOD2 and breast cancer.