As colorectal carcinogenesis is very heterogeneous there might be even different connections between EMT and ER-stress in different types of colorectal tumors including microsatellite instable tumors (characterized by the absence of human MUT-L homologue 1 (hMLH1) expression) or tumors without dysregulated Wnt/β-catenin signalling [49]. Here, MLH1 is linked to colorectal neoplasm.