In central areas of tumors, where tumor cells displayed an epithelial phenotype, β-catenin was found mainly associated with the membrane (16/16 cases, 100%), while weak or absent staining was observed for GRP78 (14/16 cases, 88%) and HIF1α (16/16 cases, 100%) in all tumor cells (Figure 3 A–C). The gene discussed is HIF1A; the disease is neoplasm.