In addition to S34F/Y mutations, eight other somatic mutations were observed in U2AF1. To identify transcriptome alterations associated with U2AF1 mutation, we focused on lung adenocarcinoma and AML as these cancer types have a higher frequency of mutations and thus would have more power to detect statistically significant changes associated with the mutation and control for differences between tissue of origin. The gene discussed is U2AF1; the disease is acute myeloid leukemia.