Using available data from 12 TCGA cancer types [9], we identified cancer harboring somatic mutations in U2AF1. Across 2,979 cancer specimens with both whole-exome sequencing and RNA-Seq, 26 had missense mutations in U2AF1—17 at amino acid position 34 (Table S1 in Document S1, Figure 1). This evidence concerns the gene U2AF1 and cancer.