U2AF1 and lung adenocarcinoma: In addition to S34F/Y mutations, eight other somatic mutations were observed in U2AF1. To identify transcriptome alterations associated with U2AF1 mutation, we focused on lung adenocarcinoma and AML as these cancer types have a higher frequency of mutations and thus would have more power to detect statistically significant changes associated with the mutation and control for differences between tissue of origin.