These authors demonstrated that the lactate transporter, monocarboxylate transporter 1 (MCT1), which is expressed in oligodendroglia, is involved in lactate transport from glia to axons, and in ALS, glial MCT1 levels were found reduced, leading to reduced lactate transport to axons, which may contribute to the pathogenesis of ALS. This evidence concerns the gene SLC16A1 and amyotrophic lateral sclerosis.