To which extent ribosomal transfer from Schwann cells to axons plays a functional role in the pathogenesis of ALS remains to be determined, but the reported finding that selective reduction of an ubiquitously expressed dismutase active SOD1 in Schwann cells in mice accelerates disease progression [49], is in line with an axon-supporting role for Schwann cells during ALS disease progression. Here, SOD1 is linked to amyotrophic lateral sclerosis.