Indeed, our data on DI suggest that whether the treatment with GH has a detrimental role on insulin resistance because it stimulates lipolysis, in youths pancreas maintains a beta-cell compensatory capacity and is able to answer to a relative hyperglycemia with a higher insulin secretion which counterbalances the GH inhibited insulin-stimulated glucose uptake in the muscles without impact on future type 2 diabetes risk in those healthy [4], [5]. This evidence concerns the gene INS and type 2 diabetes mellitus.