Table 3 displays the multivariate associations between incident AMD and the novel gene variants in two models: A) adjusted for demographic, environmental and macular variables, and B) controlling for the 6 genetic variants in 5 genes (referred to herein as the “6 gene model”), in addition to the non-genetic variables in Model A. In Model B, COL8A1 (CC vs TT, HR = 1.9, P = .02, P trend = 0.04), CFH R1210C (HR 2.4, P = .02) and RAD51B (GG vs AA, HR 0.80, P = .04, P trend = 0.01), were significantly related to AMD progression to advanced stages independent of the other variables. The gene discussed is RAD51B; the disease is age-related macular degeneration.