The aim of this study was to utilize microarray profiling to identify circulating miRNAs that are differentially expressed in women with Luminal A-like breast cancer (ER positive, PR positive, HER2/neu negative) in comparison to healthy controls, to validate candidate miRNA expression using RQ-PCR, investigate their expression level in association with common clinicopathological parameters, and to study their effectiveness as circulating diagnostic biomarkers in the clinical setting. Here, PGR is linked to breast cancer.