Association between APOC1 variant genotypes and increased AD risk was observed using the recessive (heterogeneity: Ph = 0.05, I2 = 39.68%; OR = 2.55, 95%CI = 1.99–3.25) (Figure 2), dominant (heterogeneity: Ph<0.001, I2 = 71.56%; OR = 1.96, 95%CI = 1.28–3.02), and overdominant (heterogeneity: Ph = 0.002, I2 = 57.59%; OR = 1.57, 95%CI = 1.12–2.22) models. This evidence concerns the gene APOC1 and Alzheimer disease.