Although the association between the APOC1 rs11568822 polymorphism and AD risk has been hotly debated in many studies [9], [10], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], the results of these studies are conflicting and ambiguous, partially due to the relatively small sample size of individual studies and a wide range of ethnic groups. This evidence concerns the gene APOC1 and Alzheimer disease.