AFP and hepatocellular carcinoma: Moreover, high pre-treatment serum AFP-L3% was also highly related with DFS in HCC patients treated by RFA and multiple treatment (HR: 1.73, 95% CI: 1.10–2.71, p = 0.02; HR: 1.72, 95% CI: 1.27–2.32, p = 0.0004, respectively), without strong evidence for heterogeneity (x2 = 1.12, I2 = 10%, p = 0.29; x2 = 0.48, I2 = 0%, p = 0.49, respectively).