AFP and hepatocellular carcinoma: Although the subgroup analysis revealed that the prognostic effects of high serum AFP-L3% on OS and DFS in HCC patients were similar for highly sensitive and conventional AFP-L3 detection method (x2 p-value for subgroup differences >0.05), there was a trend that the summary HR on DFS from eligible studies on highly sensitive AFP-L3 detection method was distinct from the conventional AFP-L3 detection method, supporting the predictive value of highly sensitive AFP-L3 detection method on DFS (x2 p-value for subgroup differences = 0.08).