IRS2 and cancer: Another IRS2 rs1805097(G>A) polymorphism, a nonsynonymous SNP that was predicted to affect splicing, transcriptional regulation, and post-translational modification, is common [minor allele frequency (MAF)  = 0.30] (http://www.ncbi.nlm.nih.gov/SNP) and most frequently studied for the association with cancer risk, especially colorectal and breast cancer [18], [20], [21], [27]–[30].