Ramachandran et al. found that the XRCC1 Arg399Gln polymorphism was associated with increased risk of oral cancer in an Indian population [10], while Kostrzewska-Poczekaj et al. found that XRCC1 Arg399Gln was a protective factor for squamous cell carcinoma of the head and neck in young adults [52]. Here, XRCC1 is linked to lip and oral cavity carcinoma.