TARDBP and amyotrophic lateral sclerosis: In another very recent report, it was shown that a few TDP-43 inclusions of ALS patients may consist of 10–20 nm fibrils able to bind ThS, but such features were found only in a small fraction of skein-like inclusions of the spinal cord, with amyloid-like characteristics being absent in most spinal cord skeins and absent altogether in other TDP-43 inclusions of the spinal cord and in all inclusions of the brain [13].