MMP2 and relapsing-remitting multiple sclerosis: Statins inhibit the STAT1 phosphorylation which is an important signaling pathway for IFNB, antagonize the inhibitory effect of IFNB on the proteolytic activity on MMP-2 and MMP-9, and reduce IFNB function and type 1 interferon responses in RRMS patients [34]–[37].