Work from this laboratory identified new anti-tumor action exerted by drugs classically used for the treatment of benign prostatic hyperplasia (quinazoline-α1-adrenoceptor antagonists) via induction of the extrinsic apoptosis cascade (death receptor activation, caspase-8 cleavage and inhibition of AKT survival signaling) [3], [4], [5]. The gene discussed is AKT1; the disease is neoplasm.