Interestingly, CXCR7 mRNA was highly upregulated in BM samples from ALL patients compared to normal hematopoietic cell samples (0.68 [0.17 to 14.1] versus (vs.)700.2 [600.1 to 809.8], P<0.0001) and to MDS and AML patient samples, respectively (700.2 [600.1 to 809.8] versus (vs.)(0.73 [0.04–15.5]; 1.33 [0.03–8.65], P<0.0001). The gene discussed is ACKR3; the disease is acute myeloid leukemia.