Also, we analyzed whether the CD4/CD8 ratio may remain independently associated to non-AIDS events in subjects with successful immunological response to ART by re-applying the model in the subgroup of patients with CD4 counts >350 cells/μL (N = 298), and subjects with low CD4/CD8 ratio displayed increased risk of non-AIDS events (per quartile decrease, OR, 6.6; 95% CI, 2.0–21.1). The gene discussed is CD8A; the disease is AIDS.