CD8A and AIDS: In the multivariate analysis, after adjusting by gender, age, nadir CD4, date of ART initiation and cumulative ART exposure, subjects with lower CD4/CD8 ratio displayed greater risk of non-AIDS events (per quartile decrease; OR 2.6; 95% CI, 1.7–4.0; for CD4/CD8 ratio <0.4; OR, 5.1; 95% CI, 2.3–12.4).