In the conditional logistic regression in the group of 200 subjects matched by age, gender, nadir CD4 and CD4+ T-cell count and adjusted by date of ART initiation and cumulative ART exposure, we observed comparable associations between the CD4/CD8 ratio and non-AIDS events (per quartile decrease; OR, 2.9; 95% CI, 1.3–6.1; for CD4/CD8 ratio <0.4; OR, 5.4; 95% CI, 1.9–27.0). The gene discussed is CD8A; the disease is AIDS.