In conclusion, by a proteomic approach, the sera of HBV, HCV associated HCC and non-B non-CHCC have shown different protein patterns such as increased expression of LRG in HBV-HCC compared to non-B non-CHCC, and decreased expression of HP α-2 isoforms in HCV-HCC compared to non-B non-CHCC. This evidence concerns the gene LRG1 and hepatocellular carcinoma.