HP α-2 isoforms (3 spots), HP β isororm (2 spots), and CLU and Zinc-α-2-glycoprotein were down- regulated in HCV-HCC compared to non-B non-C-HCC, but Immunoglobulin (Ig) J chains (2 spots) were upregulated in HCV-HCC compared to non-B non-CHCC (Figure 3). The gene discussed is HP; the disease is hepatocellular carcinoma.