A striking result was that non-skin cancer significantly (p = 0.029 for multiplicative interaction of cancer with ApoE) differentiated the e4-specific risks of death for women from the more homogeneous group (with moderate lifespans of 70 to 95 years) increasing them by 52% from RR = 1.36 (p = 3.8×10−3) for women who did not have cancer to RR = 2.07 (p = 5.0×10−7) for women who had cancer (Figure 4B and Table 3). The gene discussed is APOE; the disease is skin cancer.