Interestingly, the risk associated with the G allele of rs10486567 in the JAZF1 intron creates an NKX3-1 binding site while destroying a FOXA1 binding site in line with the DHT-dependent decrease in enhancer activity; we would hypothesize that JAZF1 is likely a tumor suppressor influenced by this enhancer. The gene discussed is JAZF1; the disease is neoplasm.