Overall, 20 DNA-binding transcription factors are directly associated with 35 out of 77 independent prostate cancer GWAS loci: HNF1B, AR, CTBP2, RFX6, OTX1, HOXB13, PAWR, FOXP4, ZNF652, ZBTB38, VDR, NCOA4, JAZF1, NKX3-1, VGLL3, MDM4, MYC, KLF4, KLF5 and HDAC7. The gene discussed is KLF4; the disease is prostate cancer.