Indeed, the gut-associated lymphoid tissue (GALT) harbors the greatest concentration of potential HIV-1 target cells in the human body [9]; >50% of CD4 T cells from the lamina propria in the lower GI tract are destroyed during acute HIV-1 infection, and early infection of the GALT is believed to be central to chronic HIV-1 infection and disease progression [10], [11]. This evidence concerns the gene CD4 and HIV-1 infection.