The use of a complementary approach with a mouse model of genetic ablation of α2 subunit in the context of FASN overexpression underscored the crucial role of AMPK pathway in PCa progression, previously demonstrated for other tumor models (Huang et al, 2008; Faubert et al, 2013) and further supports the potential of targeting AMPK axis for PCa treatment. This evidence concerns the gene FASN and posterior cortical atrophy.